Complexes of 2-amino-4-thiazoleacetic acid hydrazide(ATAH), salicylaldehyhde-2-amino-4-thiazoleacetic acid hydrazone (ATASH) And acetone-2-amino-4-thiazoleacetic acid hydrazone(ATAAH) each with nickel(II)sulphate As proposed drugs
##article.abstract##
Complexes obtained from 2-amino-4-thiazoleacetic acid hydrazide [keto- (ATAH) and enol- (ATA) forms), salicylaldehyde- 2-amino-4-thiazoleacetic acid hydrazone (ATASH) and acetone -2-amino-4-thiazoleacetic acid hydrazone (ATAAH) were each complexed with nickel(II) sulphates. These complexes synthesized are hopefully meant to be further processed as potential drugs. The complexes were characterized by elemental analyses, conductance, infrared and electronic spectral studies. The ligands and complexes were screened for antimicrobial activity and one of the compounds was relatively active against the organism tested. The active compound is nickel-2-amino-4-thiazoleacetic acid hydrazide [Ni(ATAH)3]SO4 H2O. The electronic data indicate octahedral coordination for the all the complexes synthesized. The IR spectra data are diagnostic of bidentate coordination via the carbonyl oxygen and the azomethine, the SO42- anions are in their inner coordination spheres. The conductivity analyses indicate a non-electrolytic nature for the chelates.
References
Enedoh M. C and Nwabueze J. N (2011): “Complexes of 4-Cyanobenzaldehydecyclohexylacetic acid hydrazone with some M(II) sulphates and Acetates. (M= Ni, Cu, Co, Zn)”. Zuma Journal of Pure & Applied Sciences. 9, 1
Francisco H.N, Nuria A, Illan-Cabeza M, Antonio N and Penas-Chamorro L (2000): “Ni(II), Cu(II), Zn(II) and Cd(II) complexes of di negative N, O-tridentate uracil derived hydrazones” Acta Chimica Slovakia; 47, 481.
Ikekwere P.O, Patel K.S and Nwabueze J.N (1989): “Complexes of copper(II) sulphate with some cyclocarboxylic acid hydrazides” Synthesis and Reactivity in Inorganic Metal Organic, 19, 599
Ikekwere P.O, Patel K.S and Nwabueze J.N (1989): “Complexes of cobalt(II) sulphate with some cyclocarboxylic acid hydrazides” Synthesis and Reactivity in Inorganic Metal Organic, 19, 893
Jeffrey G.H, Basset J, Nendham J. and Dennry R.C (1979): “ Vogel’s Textbook of Qualitative Inorganic Analysis”. 4th Ed. Longman, London pp 504
Mallikarjuna B.P, Sastry B.S, Rajendraprasad Y and Chandrashekar S.M, Sathisha K (2009): “Synthesis of new 4-isopropylthiazole hydrazide analogs and some derived clubbed triazole,
oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents” To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. European Journal of Medicinal Chemistry 10, 1016
Mallikarjuna B.P, Sastry B.S, Suresh Kumar G.V, Rajendraprasad Y and Chandrashekar S.M, Sathisha K..(2008): “Synthesis of new isopropylthiazole hydrazide analogs and some derived clubbed triazole, oxadiazole ring systems--a novel class of potential antibacterial, antifungal and antitubercular agents”. Department of Medicinal Chemistry, PES College of Pharmacy,
Hanumantha Nagar, BSK Ist Stage, Bangalore 560050, Karnataka, India. mallibp@gmail.com
Nwabueze J. (1992): “ Studies on some metal (II) sulphate chelates of acetone benzoyl and acetone salicyloylhydrazones”. Journal of the Chemical Society of Nigeria, 17, 41.
Nwabueze J.N (1999): “Mixed ligand of cobaloxime with hydrazones derived from cyclocarboxylic acids” Zuma Journal of Pure and Applied Sciences, 2, 35
Nwabueze J.N, (1997): “Complexes of copper (II) with acetone hydrazones derived from some cyclocarboxylic acids” Synthesis and Reactivity in Inorganic Metal Organic Chemistry. 27, 673
